Journal
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 34, Issue 2, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2019.101365
Keywords
aldosterone-producing adenoma; bilateral adrenal hyperplasia; prevalence; aldosterone; renin; adrenal venous sampling
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Funding
- European Research Council under the European Union's Horizon 2020 research and innovation programme [694913]
- Deutsche Forschungsgemeinschaft [314061271 - TRR 205]
- DFG [RE 752/20-1]
- Else Kroner-Fresenius Stiftung [2013_A182, 2015_A171]
- China Scholarship Council
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Primary aldosteronism (PA) is the most common potentially curable form of hypertension. The overproduction of aldosterone leads to an increased risk of cardiovascular and cerebrovascular events as well as adverse effects to the heart and kidney and psychological disorders. PA is mainly caused by unilateral aldosterone excess due to an aldosterone-producing adenoma or bilateral excess due to bilateral adrenocortical hyperplasia. The diagnostic work-up of PA comprises three steps: screening, confirmatory testing and differentiation of unilateral surgically-correctable forms from medically treated bilateral PA. These specific treatments can mitigate or reverse the increased risks associated with PA. Herein we summarise the prevalence, outcomes and current and future clinical approaches for the diagnosis of primary aldosteronism. (C) 2019 Elsevier Ltd. All rights reserved.
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