Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 380, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2019.112419
Keywords
Dementia; 6-Shogaol; Western diet; Mouse behavior; Fear conditioning
Categories
Funding
- Austrian Agency for International Cooperation in Education and Research (OeAD-GmbH)
- Centrefor International Cooperation Mobility (ICM)
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Dementia is a progressive cognitive diminution impeding with normal daily activities that is constantly on the increase. Currently, the estimated prevalence is 50 million affected people worldwide, a figure expected to triple within the next 30 years. While the pathophysiology of the different types of dementia is complex, likely involving the interplay between multiple genetic and environmental factors, strong evidence points towards an important link between diet and cognitive health. Here we examined the consequences of high-fat, high-sugar Western diet (HFSD)-induced obesity on cognitive performance in the fear conditioning task in mice and explored a possible beneficial effect of 6-shogaol (6S), an active constituent of ginger, in this model. Chronic exposure to HFSD significantly enhanced body weight gain in C57BL/6N mice and this effect was prevented by treatment with 6S. HFSD + vehicle-treated mice presented with a selective deficit in cued fear memory, which was not observed in HFSD + 6S-treated animals. The findings of this study provide first evidence for a beneficial effect of 6S on HFSD-induced obesity and emotional memory deficit in mice.
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