Journal
ATHEROSCLEROSIS
Volume 294, Issue -, Pages 25-32Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2019.12.001
Keywords
CADRADS; Convolutional neural network; Artificial intelligence; Coronary artery disease; Plaque characterization
Funding
- Italian Ministry of Health, Rome, Italy [RC 2017 R1061/19-CCM1125]
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Background and aims: Artificial intelligence (AI) is increasing its role in diagnosis of patients with suspicious coronary artery disease. The aim of this manuscript is to develop a deep convolutional neural network (CNN) to classify coronary computed tomography angiography (CCTA) in the correct Coronary Artery Disease Reporting and Data System (CAD-PADS) category. Methods: Two hundred eighty eight patients who underwent clinically indicated CCTA were included in this single-center retrospective study. The CCTAs were stratified by CAD-RADS scores by expert readers and considered as reference standard. A deep CNN was designed and tested on the CCTA dataset and compared to on-site reading. The deep CNN analyzed the diagnostic accuracy of the following three Models based on CAD-RADS classification: Model A (CAD-PADS 0 vs CAD-RADS 1-2 vs CAD-RADS 3,4,5), Model 1 (CAD-RADS 0 vs CAD-RADS > 0), Model 2 (CAD-PADS 0-2 vs CAD-PADS 3-5). Time of analysis for both physicians and CNN were recorded. Results: Model A showed a sensitivity, specificity, negative predictive value, positive predictive value and accuracy of 47%, 74%, 77%, 46% and 60%, respectively. Model 1 showed a sensitivity, specificity, negative predictive value, positive predictive value and accuracy of 66%, 91%, 92%, 63%, 86%, respectively. Conversely, Model 2 demonstrated the following sensitivity, specificity, negative predictive value, positive predictive value and accuracy: 82%, 58%, 74%, 69%, 71%, respectively. Time of analysis was significantly lower using CNN as compared to on-site reading (530.5 +/- 179.1 vs 104.3 +/- 1.4 sec, p = 0.01) Conclusions: Deep CNN yielded accurate automated classification of patients with CAD-RADS.
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