Journal
BMC MOLECULAR BIOLOGY
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12867-016-0073-9
Keywords
Nucleophosmin 1; DNA repair; Cancer; Apoptosis
Categories
Funding
- NHMRC [1066550, 1091589]
- ARC [DP 120103099]
- Queensland Health Senior Clinical Research Fellowship
- Advance Queensland Research Fellowship
- National Health and Medical Research Council of Australia [1066550, 1091589] Funding Source: NHMRC
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Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a protooncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.
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