Journal
APPLIED RADIATION AND ISOTOPES
Volume 157, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2019.109032
Keywords
Boron nitride nanotubes; Rare-earth; Bioapplication; Therapy; Diagnosis; Theranostics
Categories
Funding
- FAPEMIG (Fundacao de Amparo Pesquisa do Estado de Minas Gerais) [TEC -APQ-01897-16]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- CNEN (Comissao Nacional de Energia Nuclear)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [305475/2015-0]
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Boron nitride nanotubes (BNNTs) have been growing in notoriety in the development of systems aiming bioapplications. In this work we conducted an investigation about the mechanisms involved in the incorporation of samarium and gadolinium in BNNTs. The process was performed by the reduction of samarium and gadolinium oxides (Sm2O and Gd2O, respectively) in the presence of NH3 gas (witch decomposes into N-2 and H-2) at high temperatures. Various characterization techniques were conducted to elucidate how Sm and Gd are introduced into the BNNT structure. Biological in vitro assays were performed with human fibroblasts and a human osteosarcoma cell line (SAOS-2). Our results show that the studied systems have high potential for biomedical application and can be used as non-invasive imaging agents, such as scintigraphy radiotracers or as magnetic resonance imaging (MRI) contrast medium, being able to promote the treatment of many types of tumors simultaneously to their diagnosis.
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