Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 34, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/aoc.5394
Keywords
AgNPs; antibacterial activity; antioxidant property; green synthesis; Lavandula stoechas
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Funding
- Yasuj University of Medical Sciences
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Due to environmentally friendly and cost- effective issues, biological methods for silver nanoparticles (AgNPs) synthesis are advantageous over chemical and physical ones. In this study, AgNPs synthesized using Lavandula stoechas extract as a reductant and its antioxidant capacity, antibacterial property and cytotoxicity effect were investigated. The phyto-synthesized AgNPs were characterized using various analyses such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD) as well as Fourier transform infrared (FT-IR). The prepared nanoparticles were spherical on shape with the size about 20-50 nm. Antibacterial studies through agar disk diffusion method confirmed the antibacterial potential of phyto-synthesized AgNPs toward two clinical Staphylococus aureus and Pseudomonas aeruginosa bacteria, although MTT assay demonstrated that S. aureus (MIC = 125 mu g/ml) was more susceptible to AgNPs than P. aeruginosa (MIC = 250 mu g/ml). Moreover, the cytotoxicity assay of phyto-synthezied AgNPs showed a low cytotoxic effect on RAW264 cell line at 62.5 mu g/ml as an effective concentration. Also the considerable antioxidant capacity of the AgNPs confirmed through DPPH assay. Great antibacterial and antioxidant properties along with biocompatibility make the suggested phyto-synthesized AgNPs a great candidate for different biomedical applications including wound healing.
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