Common-path-based device for magnetomotive OCT noise reduction

Magnetomotive optical coherence tomography (MMOCT) is a promising imaging method for noninvasive threedimensional tracking of magnetic nanoparticle (MNP) motions in target tissues or organs. The external B-field is the driving force that provides MMOCT contrast. However, B-field modulation also introduces modulation noise, thereby decreasing the quality of the MMOCT image. In this paper, a common-path-based device is designed for modulation noise reduction. The device is capable of adjusting interference distance, reference light intensity, and imaging position (X-Y translation). The sensitivity of the MMOCT is increased by similar to 20 times with the new device. Using the proposed device, the distribution of MNPs injected in zebrafish was imaged. (C) 2020 Optical Society of America