Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 104, Issue 3, Pages 935-951Publisher
SPRINGER
DOI: 10.1007/s00253-019-10157-x
Keywords
Fat-soluble vitamins; Transgenic plant production; Microalgae biosynthetic product; Microbial production; Systems metabolic engineering
Categories
Funding
- National Natural Science Foundation of China [31871784, 31870069, 21676119, 31671845]
- Postgraduate Research & Practice Innovation Program of Jiangsu Provence [KYCX18_1786]
- Fundamental Research Funds for the Central Universities [JUSRP51713B]
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Fat-soluble vitamins are vitamins that are insoluble in water, soluble in fat, and organic solvents; they are found in minute amount in various foods. Fat-soluble vitamins, including vitamins A, D, E, and K, have been widely used in food, cosmetics, health care products, and pharmaceutical industries. Fat-soluble vitamins are currently produced via biological and chemical synthesis. In recent years, fat-soluble vitamin production by biotechnological routes has been regarded as a very promising approach. Based on biosynthetic pathways, considerable advances of alpha-tocopherol and beta-carotenes have been achieved in transgenic plants and microalgae. Microbial fermentation, as an alternative method for the production of vitamin K and beta-carotenes, is attracting considerable attention because it is an environment friendly process. In this review, we address the function and applications of fat-soluble vitamins, and an overview of current developments in the production of fat-soluble vitamins in transgenic plants, microalgae, and microorganisms. We focus on the metabolic and process engineering strategies for improving production of fat-soluble vitamins, and we hope this review can be useful for the people who are interested in the production of fat-soluble vitamins by biotechnological routes.
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