Journal
ANTIVIRAL RESEARCH
Volume 173, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2019.104650
Keywords
EV-A71; HFMD; IRES; Emetine
Categories
Funding
- NSFC [81971976, 81772236]
- Major Project of Technology Innovation Program of Hubei Province [2018ACA123]
Ask authors/readers for more resources
IRES-driven translation plays an essential role in picornavirus infection. However, there are seldom reports of compounds targeting this pathway with effective protection in animal models. Here, we identified emetine, an antiprotozoal drug, which inhibits EV-A71 with an EC50 value of 0.04 mu M and a CC50 value of 10 mu M in RD cell culture. Interestingly, emetine exhibits activities against a series of human enteroviruses, including CV-A16, CV-B1, EV-D68, Echov-6, etc., at the nanomolar level. When orally administered at 0.20 mg/kg twice a day in an EV-A71 mouse model, emetine reduced viral loads in various organs and completely prevented diseases and death. A mechanistic study demonstrated that emetine suppressed EV-A71 by inhibiting viral IRES-driven translation. Taken together, these data indicate emetine as a promising candidate to treat picornavirus infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available