Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 34, Issue 7, Pages 517-530Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2020.8058
Keywords
reactive oxygen species; mitophagy; mitochondria; metabolism
Funding
- American Cancer Society
- Susan G. Komen
- Coleman Foundation
- Malanga Family Excellence Fund for Cancer Research
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The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
Recent Advances: However, while the relationship between mitophagy and ROS production is clearly interwoven, it is yet to be fully untangled. In some circumstances, mitochondrial ROS (mtROS) are elevated as a consequence of mitophagy induction. Critical Issues: In this review, we discuss mtROS generation and their detrimental effects on cellular viability. In addition, we consider the cellular defense mechanisms that the eukaryotic cell uses to abrogate superfluous oxidative stress. In particular, we delve into the prominent mechanisms governing mitophagy induction that bear on oxidative stress. Future Directions: Finally, we examine the pathological conditions associated with defective mitophagy, where additional research may help to facilitate understanding.
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