Journal
ANTICANCER RESEARCH
Volume 39, Issue 12, Pages 6685-6691Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.13883
Keywords
2-methoxy-4-vinylphenol; cell proliferation; cell migration; hepatocyte growth factor
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [2016R1A6A1A03012862]
- Korean Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the Agri-Bio Industry Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [315027-4]
- National Research Foundation of Korea [2016R1A6A1A03012862] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Background/Aim: No effective therapeutics have yet been developed for pancreatic cancer. 2-Methoxy-4-vinyl phenol (2M4VP), a member of the class of phenols, has been demonstrated to have anti-inflammatory properties and cause cell cycle arrest making it an attractive candidate drug for the treatment of pancreatic cancer. Materials and Methods: The effects of 2M4VP were examined in Panc-1 and SNU-213 human pancreatic cancer cells. Results: 2M4VP had anticancer effects on pancreatic cancer cell lines, Panc-1 and SNU-213. 2M4VP reduced the viability of Panc-1 cells by inhibiting the expression of the cell nuclear antigen (PCNA) protein. 2M4VP also suppressed the migratory activity of both cell lines. In addition, treatment with 2M4VP effectively decreased the phosphorylation of Focal Adhesion Kinase (FAK) and AKT. Conclusion: 2M4VP might be used as a pancreatic cancer treatment supplement.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
