Journal
ANNUAL REVIEW OF NEUROSCIENCE, VOL 43
Volume 43, Issue -, Pages 73-93Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-101419-011117
Keywords
timing; animal behavior; neural circuits; interval timing; spatial navigation; episodic memory
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Funding
- Office of Naval Research [N00014-16-1-2832, N00014-19-1-2571]
- McKnight Foundation
- Simons Collaboration on the Global Brain Postdoctoral Fellowship
- Chicago Biomedical Consortium
- Searle Funds at The Chicago Community Trust
- National Institutes of Health [2R01MH101297, R01 MH120073]
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Interval timing, which operates on timescales of seconds to minutes, is distributed across multiple brain regions and may use distinct circuit mechanisms as compared to millisecond timing and circadian rhythms. However, its study has proven difficult, as timing on this scale is deeply entangled with other behaviors. Several circuit and cellular mechanisms could generate sequential or ramping activity patterns that carry timing information. Here we propose that a productive approach is to draw parallels between interval timing and spatial navigation, where direct analogies can be made between the variables of interest and the mathematical operations necessitated. Along with designing experiments that isolate or disambiguate timing behavior from other variables, new techniques will facilitate studies that directly address the neural mechanisms that are responsible for interval timing.
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