Journal
ANNUAL REVIEW OF MEDICINE, VOL 71, 2020
Volume 71, Issue -, Pages 137-148Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-med-052918-122440
Keywords
allogeneic hematopoietic cell transplant; allo HCT; graft-versus-host disease; GVHD; microbiome; antibiotics; transplant-related mortality; TRM; febrile neutropenia
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Funding
- NHLBI NIH HHS [R01 HL124112] Funding Source: Medline
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The microbiome is an integrated part of the human body that can modulate a variety of disease processes and affect prognosis, treatment response, complications, and outcomes. The importance of allogeneic hematopoietic cell transplantation in cancer treatment has resulted in extensive investigations on the interaction between the microbiome and this treatment modality. These investigations are beginning to lead to clinical trials of microbiome-targeted interventions. Here we review some of these discoveries and describe strategies being investigated to manipulate the microbiome for favorable outcomes, such as the proper selection and timing of antibiotics, type of diet and route of administration, probiotics, prebiotics, and fecal microbiota transplantation.
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