Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 22
Volume 22, Issue -, Pages 1-24Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-060418-052350
Keywords
layer-by-layer self-assembly; polyelectrolyte multilayer films; controlled drug delivery; antibacterial materials; cancer therapy; cellular engineering
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Funding
- Brown University
- Office of Naval Research [N000141712120, N000141712651]
- National Science Foundation Graduate Research Fellowship [1644760]
- U.S. Department of Defense (DOD) [N000141712651, N000141712120] Funding Source: U.S. Department of Defense (DOD)
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Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic agents; coat multiple substrates of all scales (e.g., nanoparticles to implants); and exhibit tuned, targeted, and/or responsive drug release behavior. The functional behavior of LbL films can be related to their physicochemical properties. In this review, we highlight recent advances in the development of LbL-engineered biomaterials for drug delivery, demonstrating their potential in the fields of cancer therapy, microbial infection prevention and treatment, and directing cellular responses. We discuss the various advantages of LbL biomaterial design for a given application as demonstrated through in vitro and in vivo studies.
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