4.6 Article

Effects of apple polyphenols on myofiber-type transformation in longissimus dorsi muscle of finishing pigs

Journal

ANIMAL BIOTECHNOLOGY
Volume 32, Issue 2, Pages 246-253

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/10495398.2020.1735405

Keywords

Apple polyphenols; finishing pigs; muscle fiber-type transformation; mitochondrial biogenesis and function; antioxidant capacity

Funding

  1. National Key R&D Program of China [2018YFD0500403]
  2. Specific Research Supporting Program for Discipline Construction at Sichuan Agricultural University

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The study found that adding apple polyphenols can promote the transformation of muscle fibers from fast-twitch to slow-twitch in finishing pigs, achieved by improving mitochondrial biogenesis and function as well as enhancing antioxidant capacity.
This study aimed to investigate effects of apple polyphenols (APPs) on myofiber-type transformation in longissimus dorsi muscle of finishing pigs and its mechanism. In this study, 36 healthy castrated Duroc x Landrace x Yorkshire pigs with an average body weight of 71.25 +/- 2.40 kg were randomly divided into three treatment groups (control, 0.04% APPs, 0.08% APPs). The experiment lasted for 49 days. Results showed that dietary APP supplementation increased the protein expression of MyHC I and the activities of succinic dehydrogenase and malate dehydrogenase, as well as decreased the protein expression of MyHC IIb and the activity of lactate dehydrogenase, suggesting that APPs promoted muscle fiber-type transformation from fast-twitch to slow-twitch in finishing pigs. We also showed that dietary 0.08% APP supplementation increased the expressions of mitochondrial biogenesis and function-related proteins PGC-1 alpha, Sirt1 and Cytc. In addition, dietary supplementation with 0.08% APPs increased the activities of T-SOD, GSH-PX and CAT and decreased the MDA content. Together, we provided the first evidence that APP promotes muscle fiber-type transformation from fast-twitch to slow-twitch in finishing pigs, which may be achieved by improving the mitochondrial biogenesis and function and increasing the antioxidant capacity of skeletal muscle.

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