Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 11, Pages 4406-4414Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201910615
Keywords
chirality; drug delivery; nanodrugs; selenium nanoparticles
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Funding
- Natural Science Foundation of China [21877049, 21701053]
- National Institutes of Health [P30CA014520]
- Major Program for Tackling Key Problems of Industrial Technology in Guangzhou [201902020013]
- Dedicated Fund for Promoting High-Quality Marine Economic Development in Guangdong Province [GDOE-2019-A31]
- China Postdoctoral Science Foundation [2016M602599]
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The chirality of nanoparticles directly influences their transport and biological effects under physiological conditions, but the details of this phenomenon have rarely been explored. Herein, chiral GSH-anchored selenium nanoparticles (G@SeNPs) are fabricated to investigate the effect of their chirality on their transport and antioxidant activity. G@SeNPs modified with different enantiomers show opposite handedness with a tunable circular dichroism signal. Noninvasive positron emission tomography imaging clearly reveals that Cu-64-labeled l-G@SeNPs experience distinctly different transport among the major organs from that of their d-and dl-counterparts, demonstrating that the chirality of the G@SeNPs influences the biodistribution and kinetics. Taking advantage of the strong homologous cell adhesion and uptake, l-G@SeNPs have been shown here to effectively prevent oxidation damage caused by palmitic acid in insulinoma cells.
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