Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 25, Pages 10008-10012Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201916430
Keywords
aggregation-induced emission; calixarenes; fluorescence-guided surgery; nanodots; supramolecular nanoparticles
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Funding
- NSFC [51873092, 51873090]
- Fundamental Research Funds for the Central Universities, Nankai University
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Host-guest complexation between calix[5]arene and aggregation-induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co-assembly of calix[5]arene amphiphiles and AIEgens affords highly emissive supramolecular AIE nanodots thanks to their interaction severely restricting the intramolecular motion of AIEgens, which also show negligible generation of cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis-bearing mouse model indicate that such supramolecular AIE dots have rather low in vivo side toxicity and can serve as a superior fluorescent bioprobe for ultrasensitive fluorescence image-guided cancer surgery.
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