Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 22, Pages 8476-8480Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202001162
Keywords
biometrics; DNA encryption; genomic DNA; next-generation sequencing; synthetic DNA
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Funding
- ETH Zurich
- Swiss National Science Foundation [183723]
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Today, we can read human genomes and store digital data robustly in synthetic DNA. Herein, we report a strategy to intertwine these two technologies to enable the secure storage of valuable information in synthetic DNA, protected with personalized keys. We show that genetic short tandem repeats (STRs) contain sufficient entropy to generate strong encryption keys, and that only one technology, DNA sequencing, is required to simultaneously read the key and the data. Using this approach, we experimentally generated 80 bit strong keys from human DNA, and used such a key to encrypt 17 kB of digital information stored in synthetic DNA. Finally, the decrypted information was recovered perfectly from a single massively parallel sequencing run.
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