Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 13, Pages 5321-5325Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915459
Keywords
amines; diaryl ketones; homogeneous catalysis; reductive amination; ruthenium
Categories
Funding
- National Natural Science Foundation of China [21801119]
- Shenzhen Science and Technology Innovation Committee [JCYJ20170817110055425, KQTD20150717103157174]
- Shenzhen Nobel Prize Scientists Laboratory Project [C17783101]
Ask authors/readers for more resources
A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93->99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available