Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 15, Pages 6235-6238Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201916335
Keywords
H-1 NMR; anti-z-COSY; high resolution; ultra-fast magic-angle spinning
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Funding
- Swiss National Science Foundation [200020_178860]
- Marie-Skodowska-Curie Grant [796904]
- Marie Curie Actions (MSCA) [796904] Funding Source: Marie Curie Actions (MSCA)
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The typical linewidths of H-1 NMR spectra of powdered organic solids at 111 kHz magic-angle spinning (MAS) are of the order of a few hundred Hz. While this is remarkable in comparison to the tens of kHz observed in spectra of static samples, it is still the key limit to the use of H-1 in solid-state NMR, especially for complex systems. Here, we demonstrate a novel strategy to further improve the spectral resolution. We show that the anti-z-COSY experiment can be used to reduce the residual line broadening of H-1 NMR spectra of powdered organic solids. Results obtained with the anti-z-COSY sequence at 100 kHz MAS on thymol, beta-AspAla, and strychnine show an improvement in resolution of up to a factor of two compared to conventional spectra acquired at the same spinning rate.
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