Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 8, Pages 3315-3321Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915828
Keywords
bioinorganic chemistry; cancer; cytotoxicity; iridium; medicinal chemistry
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Funding
- National Science Foundation of China [21525105, 21778079]
- 973 Program of China [2015CB856301]
- Ministry of Education of China [IRT-17R111]
- Pearl River S&T Nova Program of Guangzhou [201806010136]
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Reported is the Fe-III-activated lysosome-targeting prodrug FerriIridium for gastric cancer theranostics. It contains a meta-imino catechol group that can selectively bond to, and be oxidized by, free Fe-III inside the cell. Subsequent oxidative rearrangement releases Fe-II and hydrolyses the amine bond under acidic conditions, forming an aminobipyridyl Ir complex and 2-hydroxybenzoquinone. Thus, Fe-II catalyzes the Fenton reaction, transforming hydrogen peroxide into hydroxyl radicals, the benzoquinone compounds interfere with the respiratory chain, and conversion of the prodrug into the Ir complex leads to an increase in phosphorescence and toxicity. These properties, combined with the high Fe-III content and acidity of cancer cells, make FerriIridium a selective and efficient theranostic agent (IC50=9.22 mu m for AGS cells vs. >200 mu m for LO2 cells). FerriIridium is the first metal-based compound that has been developed for chemotherapy using Fe-III to enhance both selectivity and potency.
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