Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 25, Pages 9868-9886Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202000845
Keywords
aggregation-induced emission; AIE molecular probes; AIE nanoparticles; bioimaging; image-guided therapy
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Funding
- Singapore NRF Competitive Research Program [R279-000-483-281]
- NRF Investigatorship [R279-000-444-281]
- National University of Singapore [R279-000-482-133]
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The concept of aggregation-induced emission (AIE) has opened new opportunities in many research fields. Motivated by the unique feature of AIE fluorogens (AIEgens), during the past decade, many AIE molecular probes and AIE nanoparticle (NP) probes have been developed for sensing, imaging and theranostic applications with excellent performance outperforming conventional fluorescent probes. This Review summarizes the latest advancement of AIE molecular probes and AIE NP probes and their emerging biomedical applications. Special focus is to reveal how the AIE probes are evolved with the development of new multifunctional AIEgens, and how new strategies have been developed to overcome the limitations of traditional AIE probes for more translational applications via fluorescence imaging, photoacoustic imaging and image-guided photodynamic/photothermal therapy. The outlook discusses the challenges and future opportunities for AIEgens to advance the biomedical field.
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