Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 12, Pages 4711-4719Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201914970
Keywords
cytosolic delivery; dendrimers; enzymes; protein delivery; peptide delivery
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Funding
- National Key R&D Program of China, Synthetic Biology Research [2019YFA0904500]
- National Natural Science Foundation of China [21725402]
- Shanghai Municipal Science and Technology Commission [17XD1401600, 188014580]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06C322]
- Flow Cytometry Core Facility
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A coordinative dendrimer delivers 30 types of cargo proteins and peptides into the cytosol of living cells, while maintaining their bioactivity after intracellular release. In their Research Article (DOI: 10.1002/anie.201914970), Y. Cheng et al. report that dendrimers modified with a dipicolylamine/zinc (II) complex are capable of binding proteins through a combination of ionic and coordination interactions. This provides a new strategy to develop robust and efficient polymers for cytosolic protein delivery.
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