Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 7, Pages 2750-2754Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201913825
Keywords
1; 4-addition; cross-coupling; cyclobutenones; hydrosilylation; tandem reactions
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Funding
- National Natural Science Foundation of China [21772024, 21921003]
- 1000-Youth Talents Program
- Fudan University
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A copper-catalyzed tandem process to generate chiral cyclobutene derivatives has been developed. It is based on an enantioselective conjugate addition or reduction of a cyclobutenone and sequential trapping with a chlorophosphate in a one-pot process. These phosphates are stable under mildly acidic conditions and serve as good electrophiles in Negishi coupling reactions.
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