Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 7, Pages 2720-2724Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201910979
Keywords
biomimetic hydrogels; photodynamic antimicrobial chemotherapy; polyisocyanides; polythiophene; strain stiffening
Categories
Funding
- National Natural Science Foundation of China [21574037, 21773054, 51803046]
- 100 Talents Program of Hebei Province, China [E2014100004]
- Natural Science Foundation of Hebei Province [B2017202051]
- Program for Top 100 Innovative Talents in Colleges and Universities of Hebei Province [SLRC2017028]
Ask authors/readers for more resources
Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)-generation efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed of helical tri(ethylene glycol)-functionalized polyisocyanides (PICs) and a conformation-sensitive conjugated polythiophene, poly(3-(3 '-N,N,N-triethylammonium-1 '-propyloxy)-4-methyl-2,5-thiophene chloride) (PMNT). The PIC polymer serves as a scaffold to trap and align the PMNT backbone into a highly ordered conformation, resulting in redshifted, new sharp bands in the absorption and fluorescence spectra. Similar to PIC, the hybrid closely mimics the mechanical properties of biological gels, such as collagen and fibrin, including the strain stiffening properties at low stresses. Moreover, the PMNT/PIC hybrids show much higher ROS production efficiency under red light than PMNT only, leading to an efficient photodynamic antimicrobial effect towards various pathogenic bacteria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available