Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 12, Pages 4729-4735Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201914119
Keywords
F-19 MRI; bioconjugation; in vivo tracking; low-fouling fluoropolymers; thermoresponsive materials
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Funding
- Australian Research Council [CE140100036, DP0987407, DFP110104299, DFP180101221, LE0775684, LE0668517, LE0882357]
- National Health and Medical Research Council [APFP1021759, APP1118881, APP1105420]
- University of Queensland [UQFEL1831361]
- Queensland Cyber Infrastructure Foundation (QCIF)
- University of Queensland Research Computing Centre
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The conjugation of hydrophilic low-fouling polymers to therapeutic molecules and particles is an effective approach to improving their aqueous stability, solubility, and pharmacokinetics. Recent concerns over the immunogenicity of poly(ethylene glycol) has highlighted the importance of identifying alternative low fouling polymers. Now, a new class of synthetic water-soluble homo-fluoropolymers are reported with a sulfoxide side-chain structure. The incorporation of fluorine enables direct imaging of the homopolymer by F-19 MRI, negating the need for additional synthetic steps to attach an imaging moiety. These self-reporting fluoropolymers show outstanding imaging sensitivity and remarkable hydrophilicity, and as such are a new class of low-fouling polymer for bioconjugation and in vivo tracking.
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