Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 17, Pages 6740-6744Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915944
Keywords
alpha-ketoacetals; amines; heterocycles; synthetic methods; triazoles
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Funding
- GlaxoSmithKline
- EPSRC [EP/S035990/1]
- EPSRC [EP/S035990/1] Funding Source: UKRI
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A scalable metal-, azide-, and halogen-free method for the synthesis of substituted 1,2,3-triazoles has been developed. The reaction proceeds through a 3-component coupling of alpha-ketoacetals, tosyl hydrazide, and a primary amine. The reaction shows outstanding functional-group tolerance with respect to both the alpha-ketoacetal and amine coupling partners, providing access to 4-, 1,4-, 1,5-, and 1,4,5-substituted triazoles in excellent yield. This robust method results in densely functionalised 1,2,3-triazoles that remain challenging to prepare by azide-alkyne cycloaddition (AAC, CuAAC, RuAAC) methods and can be scaled in either batch or flow reactors. Methods for the chemoselective reaction of either aliphatic amines or anilines are also described, revealing some of the potential of this novel and highly versatile transformation.
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