Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 12, Pages 4720-4728Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201913539
Keywords
drug loading; hydrophobic drugs; nanoprecipitation; polymer nanoparticles
Categories
Funding
- Australian Research Council [FT140100726]
- National Science Foundation [DMR1310266]
- Harvard Materials Research Science and Engineering Center [DMR-1420570]
- Australian Government Research Training Program Scholarships
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Poor solubility often leads to low drug efficacy. Encapsulation of water-insoluble drugs in polymeric nanoparticles offers a solution. However, low drug loading remains a critical challenge. Now, a simple and robust sequential nanoprecipitation technology is used to produce stable drug-core polymer-shell nanoparticles with high drug loading (up to 58.5 %) from a wide range of polymers and drugs. This technology is based on tuning the precipitation time of drugs and polymers using a solvent system comprising multiple organic solvents, which allows the formation of drug nanoparticles first followed by immediate precipitation of one or two polymers. This technology offers a new strategy to manufacture polymeric nanoparticles with high drug loading having good long-term stability and programmed release and opens a unique opportunity for drug delivery applications.
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