Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 18, Pages 7184-7187Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201916025
Keywords
amino acids; biocatalysis; methyltransferase; S-adenosylmethionine; stereoselective C-alkylation
Categories
Funding
- SSSTC
- CSC
- Professur fur Molekulare Bionik
- Proof of Concept grant from the European Research Council (ERC-2018-PoC)
- Innovationsraum Biokatalyse
Ask authors/readers for more resources
This report describes a modular enzyme-catalyzed cascade reaction that transforms l- or d-alpha-amino acids to beta-methyl-alpha-amino acids. In this process an alpha-amino acid transaminase, an alpha-keto acid methyltransferase, and a halide methyltransferase cooperate in two orthogonal reaction cycles that mediate product formation and regeneration of the cofactor pyridoxal-5 '-phosphate and the co-substrate S-adenosylmethionine. The only stoichiometric reagents consumed in this process are the unprotected l- or d-alpha-amino acid and methyl iodide.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available