Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 13, Pages 5108-5115Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201912182
Keywords
antioxidants; enzyme mimics; reactive oxygen and nitrogen species; sepsis; single-atom catalysts
Categories
Funding
- Natural Science Foundation of China [21533008, 91856205, 21871249, 21820102009]
- Key Program of Frontier of Sciences [CAS QYZDJ-SSW-SLH052]
Ask authors/readers for more resources
Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen species (RONS), causes high morbidity and mortality. Despite progress made with nanozymes, efficient antioxidant therapy to eliminate these RONS remains challenging, owing largely to the specificity and low activity of exploited nanozymes. Herein, an enzyme-mimicking single-atom catalyst, Co/PMCS, features atomically dispersed coordinatively unsaturated active Co-porphyrin centers, which can rapidly obliterate multiple RONS to alleviate sepsis. Co/PMCS can eliminate O-2(.-) and H2O2 by mimicking superoxide dismutase, catalase, and glutathione peroxidase, while removing (OH)-O-. via the oxidative-reduction cycle, with markedly higher activity than nanozymes. It can also scavenge (NO)-N-. through formation of a nitrosyl-metal complex. Eventually, it can reduce proinflammatory cytokine levels, protect organs from damage, and confer a distinct survival advantage to the infected sepsis mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available