Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 21, Pages 7990-8003Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201913382
Keywords
alkenes; regioselectivities; reaction mechanisms; synthetic methods; transition metals
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Funding
- National Natural Science Foundation of China [21702151, 21871211, 21801193]
- Fundamental Research Funds for Central Universities [2042019kf0208]
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The direct difunctionalization of alkenes, a cheap and abundant feedstock, represents one of the most attractive strategies for increasing molecular complexity in synthetic organic chemistry. In contrast with the 1,2-difunctionalization of alkenes, recent advances showcase alkene 1,n-difunctionalizations (n not equal 2) involving metal migration is an emerging and rapidly growing area of research. This promising strategy not only opens a novel avenue for future development of alkene transformations, but also significantly expands upon the bond disconnections available in modern organic synthesis. This Minireview summarizes recent progress in the migratory difunctionalization of alkenes, with an emphasis on the driving force for metal migration.
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