Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 23, Pages 8766-8775Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915643
Keywords
foldamers; macromolecular chemistry; oligomers; supramolecular chemistry; supramolecular elements
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Chemistry beyond the molecule is based on weak, noncovalent, and reversible interactions. As a consequence of these bonds being weak, structural organization by folding and self-assembly can only be fully exploited with larger molecules that can provide multiple binding sites. Such supramolecules can now be synthesized and their folding into desired conformations predicted. A new level of chemistry can now be realized through the creation of non-natural entities composed of molecular building blocks with defined secondary structures. Herein we define these building blocks as supramolecular elements. We anticipate that further research on such large molecules will reveal construction principles dictated by recurring motifs that govern structure formation through folding and self-assembly. These principles are comparable to the organization of atoms in the Periodic Table of Chemical Elements and may lead to the establishment of a Periodic System of Supramolecular Elements.
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