Journal
ANALYTICAL BIOCHEMISTRY
Volume 598, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2020.113645
Keywords
Schiff base; Ln(III) complexes; Characterization; Photophysical properties; Antimicrobial screening; CT-DNA binding; Antioxidant efficiency; Cytotoxic activity
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New lanthanide complexes (1-3) of the general formulae [Ln(L)(NO3)(H2O)] have been synthesized by reaction of Ln(NO3)(3) {Ln = La (1), Sm (2) and Yb (3)} with 2,2'-(((1E,1'E)-thiophene-2,5-diylbis(methaneylylidene))bis(azaneylylidene))diphenol (H2L). Based on elemental analysis, spectroscopic studies (UV-Vis., FT-IR, ESI-MS, H-1/C-13 NMR), molar conductance and thermogravimetric analysis, the Schiff base ligand was suggested to co-ordinate Ln(III) ions through the azomethine nitrogens, deprotonated hydroxyl groups, and thiophene sulphur atom. The interaction of the synthetic compounds with CT-DNA has been studied by the electronic spectroscopy, fluorometric competition studies with ethidium bromide and DNA viscosity measurements. Furthermore, due to the ligand and its Ln(III) complexes exhibit good DNA binding affinity, it is considered worthwhile to investigate their antioxidant activity. The data have shown that, the complexes are more effective inhibitors towards reactive oxygen species (ROS), such as superoxide anion and hydroxyl radical. The activity of test compounds in ascending order (1) > (2) > (3) > H2L in terms of IC50 value. The anticancer activities of the complexes have also been studied towards human colon carcinoma cancer (HCT-116) and human breast cancer (MCF-7) cell lines.
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