Journal
ANALYTICA CHIMICA ACTA
Volume 1103, Issue -, Pages 75-83Publisher
ELSEVIER
DOI: 10.1016/j.aca.2019.12.057
Keywords
Uric acid; Poly (3,4-ethylenedioxythipohene); Graphene oxide; Paper-based analytical device; Human saliva
Categories
Funding
- National Natural Science Foundation of China [31741051]
- Application Research Item of Nantong City [MS12017023-1]
- Qing Lan Project of Jiangsu Province
- Jiangsu Overseas Visiting Scholar Program for University Prominent Young and Middle-aged Teachers and Presidents
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We developed a paper-based analytical device based on the electropolymerization of poly (3,4-ethylenedioxythipohene) (PEDOT) and graphene oxide (GO) composites on the ITO substrate for the detection of uric acid (UA) in authentic human saliva. Scanning electron microscopy, UV-vis spectrum and X-ray diffraction confirmed the formation of porous PEDOT combined with GO film during the electropolymerization process. The nanocomposite based sensor showed an enhanced electrocatalytic activity toward UA with high sensitivity and stability. We demonstrate that UA can be directly detected in undiluted saliva using the paper-based electroanalytical device with no interference from ascorbic acid and dopamine that are normally present in biological fluids. The results indicated that the developed device is promising for non-invasive monitoring of salivary UA in human body. (c) 2019 Elsevier B.V. All rights reserved.
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