Journal
ANALYTICA CHIMICA ACTA
Volume 1117, Issue -, Pages 74-88Publisher
ELSEVIER
DOI: 10.1016/j.aca.2020.01.052
Keywords
Ambient ionization; Mass spectrometry; Imaging; Biological tissue; Molecular distribution
Categories
Funding
- National Key Research and Development Program of China [2018YFD0900604, 2018YFD0900803]
- National Natural Science Foundation of China (NSFC) [21707171, 21625703, 21976168]
- Natural Science Foundation of Guangdong Province, China [2017A030310233]
- Science and Technology Planning Project of Guangzhou City [201804010298]
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Ambient mass spectrometry imaging (AMSI) is a molecular imaging technique developed in recent years for in situ and real time visualization of the distribution of chemical compounds in biological tissues without the need of labeling or staining. With the development for more than one decade, AMSI becomes a powerful molecular imaging technique in variousfields such as forensics, metabolomics, cancer diagnosis, and drug monitoring. In this review, we describe the recent advances of AMSI for imaging biological tissues in details. Three types of AMSI techniques based on different ionization mechanisms and analytical strategies are summarized, i.e., direct desorption/ionization of analytes for AMSI, desorption and then ionization of analytes for AMSI, and extraction of analytes for AMSI, and the features of them are presented from the aspects of tissue origin, target image molecule, and spatial resolution among others. In addition, future development directions for AMSI are discussed. (C) 2020 Elsevier B.V. All rights reserved.
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