Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 38, Issue 12, Pages 2487-2495Publisher
SPRINGER
DOI: 10.1007/s00449-015-1486-4
Keywords
3-Hydroxypropionic acid; Glycerol; Klebsiella pneumoniae; Gluconobacter oxydans; Two-step process
Funding
- Natural Science Foundation of China [21506057]
- Natural Science Foundation of Shanghai [2013ZR1412100]
- National major science and technology projects of China [2012ZX09304009]
- 863 Program [2012AA022201C]
- Fundamental Research Funds for the Central Universities
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In this work, a two-step process was developed for the production of 3-hydroxypropionic acid from glycerol. In the first step, glycerol was converted to 1,3-propanediol by Klebsiella pneumonia. In the second step, the 1,3-propanediol was converted into 3-hydroxypropionic acid by Gluconobacter oxydans. In a 7.0 L bioreactor, the whole process took 54 h, consumed 480 g glycerol and produced 242 g 3-hydroxypropionic acid. The conversion rate of glycerol to 3-hydroxypropionic acid was 50.4 % (g g(-1)). The final concentration of 3-hydroxypropionic acid arrived 60.5 g L-1. The process was effective for 3-HP production from glycerol and it might provide a new approach to the biosynthesis of 3-HP from a cheap starting material. Moreover, in this paper, it was first reported that the by-product of 3-hydroxypropionic acid production from 1,3-propandeiol was acrylic acid.
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