Journal
ALZHEIMERS & DEMENTIA
Volume 15, Issue 12, Pages 1507-1515Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2019.08.202
Keywords
Epidemiology; Mild cognitive impairment; Alzheimer's disease; Dementia; Neuroepidemiology; Cognitive function; Cognitive decline; Neuropsychology; Hispanics; Latinos; Hispanics/Latinos; Population neuroscience
Categories
Funding
- National Institute on Aging [R01AG048642, RF1AG054548, RF1AG061022, R21AG056952]
- National Heart, Lung, and Blood Institute (NHLBI) [N01-HC65233, N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237]
- National Institute on Minority Health and Health Disparities
- National Institute on Deafness and Other Communication Disorders
- National Institute of Dental and Craniofacial Research
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke
- NIH Institution-Office of Dietary Supplements
- [P30AG005131]
- [P30AG059299]
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Introduction: We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos. Methods: Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging-Alzheimer' s Association diagnostic criteria. Results: The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI. Discussion: MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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