Journal
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Volume 44, Issue 4, Pages 790-805Publisher
WILEY
DOI: 10.1111/acer.14306
Keywords
Endocannabinoids; Cannabinoid Receptors; Alcohol Drinking Behavior; Alcoholic Liver Disease
Categories
Funding
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [ZIAAA000351] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Endocannabinoids are lipid mediators that interact with the same cannabinoid receptors that recognize Delta(9)-tetrahydrocannabinol (THC), the psychoactive constituent of marijuana, to induce similar effects in the brain and periphery. Alcohol and THC are both addictive substances whose acute use elicits rewarding effects that can lead to chronic and compulsive use via engaging similar signaling pathways in the brain. In the liver, both alcohol and endocannabinoids activate lipogenic gene expression leading to fatty liver disease. This review focuses on evidence accumulated over the last 2 decades to indicate that both the addictive neural effects of ethanol and its organ toxic effects in the liver and elsewhere are mediated, to a large extent, by endocannabinoids signaling via cannabinoid-1 receptors (CB1R). The therapeutic potential of CB1R blockade globally or in peripheral tissues only is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available