Journal
AGING-US
Volume 12, Issue 2, Pages 1952-1964Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.102734
Keywords
Klotho; cardiovascular disease; inflammation; TNF alpha; IL10
Categories
Funding
- Instituto de Salud Carlos III (ISCIII) [PI13/01726, PI16/00024]
- Fondo Europeo de Desarrollo Regional, Union Europea (Una forma de hacer Europa Sociedad Espanola de Nefrologia and ACINEF)
- ISCIII [FI14/0003, CD16/00165]
- Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion of Consejeria de Economia, Industria, Comercio y Conocimiento, Gobierno de Canarias (ACIISI) - Fondo Social Europeo (FSE) Programa Operativo Integrado de Canarias 2014-2020, Eje 3 Te [TESIS2018010110]
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Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed to evaluate the association between Klotho and inflammatory cytokines levels in the context of human CVD. The study included 110 patients with established CVD and preserved renal function, and a control group of 22 individuals without previous history of cardiovascular events. Serum Klotho and IL10 levels were significantly lower in the CVD group. Inflammatory status, marked by the TNF alpha/IL10 ratio and the C-reactive protein (CRP) levels, was significantly increased in the group of patients with established CVD. Soluble Klotho levels were directly correlated with eGFR (r=0.217) and IL10 (r=0.209) and inversely correlated with age (r=-0.261), CRP (r=-0.203), and TNF alpha/IL10 (r=-0.219). This association with TNF alpha/IL10 remained significant in age-matched subgroups. Multiple logistic regression analysis showed that age, smoking and the neutrophil-to-lymphocyte ratio (NLR) constituted risk factors for the presence of CVD, while Klotho was a protective factor. In conclusion, in patients with established CVD, the reduction in soluble Klotho is associated with a pro-inflammatory status marked by lower IL10 concentrations and higher TNF alpha/IL10 ratio and CRP levels.
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