Journal
AGEING RESEARCH REVIEWS
Volume 57, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2019.100979
Keywords
Aging; microRNA; Stem cell; Extracellular vesicles; Exosomes; Therapy
Categories
Funding
- Kidney For Dane Community
- Akiko Yamzaki and Jerry Yang Faculty Scholar Fund in Pediatric Translational Medicine
- Stanford Maternal and Child Health Research Institute
Ask authors/readers for more resources
Organismal aging involves the progressive decline in organ function and increased susceptibility to age-associated diseases. This has been associated with the aging of stem cell populations within the body that decreases the capacity of stem cells to self-renew, differentiate, and regenerate damaged tissues and organs. This review aims to explore how aging is associated with the dysregulation of stem cell-derived extracellular vesicles (SCEVs) and their corresponding miRNA cargo (SCEV-miRNAs), which are short non-coding RNAs involved in post-transcriptional regulation of target genes. Recent evidence has suggested that in aging stem cells, SCEV-miRNAs may play a vital role regulating various processes that contribute to aging: cellular senescence, stem cell exhaustion, telomere length, and circadian rhythm. Hence, further clarifying the age-dependent molecular mechanisms through which SCEV-miRNAs exert their downstream effects may inform a greater understanding of the biology of aging, elucidate their role in stem cell function, and identify important targets for future regenerative therapies. Additionally, current studies evaluating therapeutic role of SCEVs and SCEV-miRNAs in treating several age-associated diseases are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available