Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 11, Pages 2216-2222Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000018
Keywords
Nitrogen Centered Radical; Photocatalysis; Traceless Nitrogen Activator; Phthalazines
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Phosphoramidates are for the first time presented as efficient N-Centered Radical (NCR) precursors under visible-light irradiation. More precisely among this class of phosphorus-derived compounds, we studied the radical reactivity of phosphonohydrazones, under mild reaction conditions, which allowed the synthesis of a wide and diversified library of the scarcely reported phthalazine scaffold. Mechanistic investigations confirmed the formation of a NCR from these brand-new phosphonohydrazones (derivatived from phosphoramidates), which were further engaged in an intramolecular 6-exo-dig cyclization to provide phthalazines. Compared to other pre-activated moieties, the phosphoramidate group is self-immolative, thus enhancing its attractiveness for the C-N bond formation.
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