Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 6, Pages 1298-1302Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901631
Keywords
spiro[5.n (n=6-8)]heterocycles; one-pot; ring-expansion; Cu-catalyzed; Csp(2)-H functionalization
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Funding
- National Natural Science Foundation of China [21871087]
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A cascade procedure for the efficient and atom-economical synthesis of spiro[5.n (n=6-8)]heterocycles has been developed. This process goes through the tandem reactions of base-promoted ring-expansion of cyclic ketones followed by Cu-catalyzed intramolecular C-2 spirocyclization of indoles. Easily accessible starting materials and broad substrate scope are the advantaged features of this protocol.
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