4.7 Article

Photoredox-Catalyzed Redox-Neutral Minisci C-H Formylation of N-Heteroarenes

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 11, Pages 2155-2159

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901481

Keywords

Formylation; Minisci reaction; N-heteroarenes; Photoredox catalysis; Redox-neutral conditions

Funding

  1. National Natural Science Foundation of China [21732002, 21672117]
  2. Tianjin Research Innovation Project for Postgraduate Students [2019YJSB085]

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We report a protocol for redox-neutral Minisci C-H formylation of N-heteroarenes using 1,3-dioxoisoindolin-2-yl 2,2-diethoxyacetate as a formyl equivalent at room temperature. This scalable benchtop protocol offers a distinct advantage over traditional reductive carbonylation and Minisci C-H formylation methods in not requiring the use of carbon monoxide, pressurized gas, a stoichiometric reductant, or a stoichiometric oxidant.

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