Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 3, Pages 688-694Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901300
Keywords
Mn(III)-mediated; regioselective; 6-endo-trig radical cyclization; 2-functionalized quinolines; o-vinylaryl isocyanides
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Funding
- National Natural Science Foundation of China [21501010, 21971224]
- China Postdoctoral Science Foundation [2019M652561]
- Key Research Projects of Universities in Henan Province [20A150006, 20B150021]
- Henan Province Young Talents Elevation Program [2019HYTP023]
- Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation [2019CL03]
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A Mn(III)-mediated radical cyclization reaction of o-vinylaryl isocyanides and arylboronic acids or diphenylphosphine oxides to access various 2-functionalized quinolines under mild conditions was developed. With the introduction of radical stabilizing substituents (e. g. aryl and methyl group) on vinyl group, this reaction provides a regiospecific 6-endo-trig radical cyclization of o-vinylaryl isocyanides, giving a number of structurally unique and biologically potential 2-functionalized quinoline derivatives.
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