Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 3, Pages 545-551Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901132
Keywords
phosphine; azepines; cycloaddition; aldimine esters; allenoates
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Funding
- National Natural Science Foundation of China [21102179, 21572271]
- Qing Lan Project of Jiangsu Province
- 'Double First-Class' University project [CPU2018GY35, CPU2018GF02]
- Postgraduate Scientific Research Innovation Projects of Jiangsu Province [KYCX19_0624]
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Text. A general method for the synthesis of structural diversity and complexity of azepines from aldimine esters and beta '-acetoxy allenoates is reported. Under phosphine catalysis, a [4+3] cycloaddition for the formation of 1,3-dihydro-2H-azepine-2,2,4-tricarboxylates was achieved with broad substrate scope under mild reactions. A switchable process was given and a variety of important 2,3-dihydrochromeno[4,3-b]azepin-6(1H)-ones were selectively formed when the reaction was performed in the presence of Cs2CO3 and PPh3, which involved an intramolecular ester group migration and subsequent lactonization of 1,3-dihydro-2H-azepine-2,2,4-tricarboxylates. Besides easy handle process, high synthetic value of resulting products, it is worth to note that this work showed the novel example of 1,5-ethoxycarbonyl migration.
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