Journal
ADVANCED MATERIALS
Volume 32, Issue 18, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201904511
Keywords
fiber architecture; fiber-reinforced hydrogel; hydrogel; ligaments; synthetic biomaterials; tendons
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Funding
- Australian Research Council Training Centre for Innovative Bioengineering
- Australian National Health and Medical Research Council
- Radcliffe Institute for Advanced Study at Harvard University
- Rebecca L. Cooper Medical Research Foundation
- strategic alliance University Medical Center Utrecht-Technical University Eindhoven
- Regenerative Medicine Crossing Borders
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Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both the unique biological and biomechanical properties of these tissues. Long-term clinical outcomes of synthetic scaffolds relying solely on high uniaxial tensile strength are poor with high rates of implant rupture and synovitis. Ideal biomaterials for T/L repair and regeneration need to possess the appropriate biological and biomechanical properties necessary for the successful repair and regeneration of ruptured tendon and ligament tissues.
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