4.5 Article

Evaluation of the Dot-ELISA as a diagnostic test for human strongyloidiasis based on the detection of IgA in saliva

Journal

ACTA TROPICA
Volume 203, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.actatropica.2019.105305

Keywords

strongyloidiasis; Immunodiagnostic; Dot-ELISA; saliva; IgA; Quick test

Funding

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [40002012026M9]
  2. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/03304-0]

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This study aimed to evaluate the use of saliva samples in the Dot-ELISA test for immunodiagnosis of human strongyloidiasis. The Dot-ELISA presented similar results to the ELISA test, with 70% and 60% sensitivity and 85% and 90% specificity, respectively, for IgA in the saliva. The Dot-ELISA with alternative saliva samples may be a suitable tool for diagnosing human strongyloidiasis, especially in populations with high levels of exposure to helminth.

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