Journal
ACTA OTO-LARYNGOLOGICA
Volume 140, Issue 2, Pages 181-187Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016489.2019.1699250
Keywords
Nivolumab; head and neck cancer; neutrophil-lymphocyte ratio; immunotherapy; survival rate; PD-1 receptor
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Background: Nivolumab has been approved for recurrent or metastatic head and neck cancer (R/M HNC) on March 2017 in Japan. Recently, many researchers have been actively studying the prognostic and predictive markers. However, they have not been clarified. In this study, we evaluate the prognostic and predictive markers of the anticancer effect of nivolumab. Objective: This study assessed baseline neutrophil-to-lymphocyte ratio (NLR) as a prognostic and predictive marker for nivolumab efficacy in patients with recurrent/metastatic head and neck cancer (R/M HNC). Material and methods: This retrospective cohort study used medical records of patients with R/M HNC treated with nivolumab from May 2017 to January 2018 at a university hospital in Japan. Results: Twenty-nine patients (median age, 64 years) were included. In univariate analyses, baseline NLR >= 5 was significantly associated with overall survival (HR 4.88; p = .045) and progressive disease (HR 5.0; p = .046). More patients with baseline NLR >= 5 changed from nivolumab to best supportive care, compared to patients with baseline NLR <5 (64.3% vs 26.7%, respectively).
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