Journal
ACS NANO
Volume 14, Issue 3, Pages 2678-2701Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c00173
Keywords
nanocarrier; nanomedicine; veterinary medicine; drug delivery; gene delivery; clinical trials; cancer; precision farming; pest management; agrochemical delivery
Categories
Funding
- National Science Foundation [DMR 1841848]
- National Institute of Health [R01 CA202814, R01 HL137674, R01CA224605, U01CA218292]
- American Cancer Society [128319-RSG-15-144-01-CDD]
- UC MEXUS-CONACYT Postdoctoral Fellowship 2019-2020 [FE-19-58]
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Nanocarrier-based delivery systems can be used to increase the safety and efficacy of active ingredients in medical, veterinary, or agricultural applications, particularly when such ingredients are unstable, sparingly soluble, or cause off-target effects. In this review, we highlight the diversity of nanocarrier materials and their key advantages compared to free active ingredients. We discuss current trends based on peer-reviewed research articles, patent applications, clinical trials, and the nanocarrier formulations already approved by regulatory bodies. Although most nanocarriers have been engineered to combat cancer, the number of formulations developed for other purposes is growing rapidly, especially those for the treatment of infectious diseases and parasites affecting humans, livestock, and companion animals. The regulation and prohibition of many pesticides have also fueled research to develop targeted pesticide delivery systems based on nanocarriers, which maximize efficacy while minimizing the environmental impact of agrochemicals.
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