Journal
ACS NANO
Volume 14, Issue 3, Pages 2982-2993Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b07851
Keywords
sperm micromotors; bloodstream; cargo delivery; heparin; rheotaxis; anticoagulation
Categories
Funding
- German Research Foundation [SPP 1726]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [835268, 853609]
- Leibniz Program of the German Research Foundation [SCHM 1298/26-1]
- Chinese Scholarship Council (CSC)
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Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments. However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood. Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery. In this biohybrid system, the sperm flagellum provides a high propulsion force while the synthetic microstructure serves for magnetic guidance and cargo transport. Moreover, single sperm micromotors can assemble into a train-like carrier after magnetization, allowing the transport of multiple sperm or medical cargoes to the area of interest, serving as potential anticoagulant agents to treat blood clots or other diseases in the circulatory system.
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